49ers run over Seahawks on 'Thursday Night Football': Highlights

Seattle Seahawks quarterback Geno Smith threw an interception to squander his team's solid first offensive drive, and things continued to go (mostly) downhill from there for Seattle.

The San Francisco 49ers took down the Seahawks, 36-24, in the Week 6 edition of "Thursday Night Football" on Amazon Prime Video. Two San Francisco rookie defenders snagged their first career interceptions in a couple of key moments, and the 49ers' offense had an apparent return to form with their highest-scoring performance of the season.

Outside of the two rookie defensive backs – Malik Mustapha and Renardo Green – it was the 49ers' run game and dominant pass-catching weapons that were the stars.

Running backs Jordan Mason and Isaac Guerendo combined for 172 yards on 19 carries. Wide receiver Deebo Samuel had his second 100-yard game of the season with a three-catch, 102-yard performance that also included a touchdown. Tight end George Kittle caught five passes for 58 yards and two touchdowns.

For the Seahawks, a kickoff return touchdown by Laviska Shenault and nice games from Tyler Lockett, Noah Fant and Jaxon Smith-Njigba were not enough to overcome what was a bad night from Smith and more than a few costly penalties.

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Along with his two picks, Seattle's quarterback often missed his targets with overthrows throughout the game, and the Seahawks ended the game with nine penalties for 69 yards.

The 49ers (3-3) take over first place in the NFC West with the win.

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USA TODAY Sports provided highlights, analysis and more from Week 6's "Thursday Night Football" matchup between the Seahawks and 49ers.

49ers vs. Seahawks highlights

49ers 36, Seahawks 24: San Francisco ices game with big run, TD

On the first play of San Francisco's next possession, rookie running back Isaac Guerendo broke off a 76-yard run to get the 49ers inside the Seahawks' 5-yard line. Two plays later, fullback Kyle Juszczyk ran between the tackles for a touchdown run that gave his team a 36-24 lead with just over a minute left to play.

49ers 29, Seahawks 24: Seattle closes gap again

The Seahawks have life after Geno Smith hit Tyler Lockett for a 9-yard touchdown pass on fourth down. With just under two minutes remaining, Seattle has cut its deficit down to five points and is electing to kick the ball off normally rather than attempting an onside kick.

It's 29-24 49ers with 1:44 remaining in the game.

49ers 29, Seahawks 17: George Kittle scores his second TD

Three plays after Renardo Green's interception, Brock Purdy found Kittle over the middle for a nine-yard touchdown throw. He threaded his pass between two Seattle defenders for his third touchdown pass — and George Kittle's second touchdown reception — of the game. The touchdown (and failed two-point conversion) added six points to the 49ers' lead. It's 29-17 San Francisco with six and a half minutes left.

Renardo Green secures his first career interception

Renardo Green becomes the second rookie in this game to snag his first career interception, following in the footsteps of fellow San Francisco defensive back Malik Mustapha, who picked off Geno Smith in the first quarter.

Green's nice play to undercut a DK Metcalf route gave the 49ers the ball in the red zone with just under eight minutes left in the game.

Deebo Samuel, George Kittle banged up

Both Deebo Samuel and George Kittle are on the sideline early in the fourth quarter after seemingly suffering injuries. Samuel appeared to hurt his hand on a play that was blown dead, but returned to the field after missing just one play. Kittle remained on the sideline for one extra play but also has returned to the field.

Stay tuned to USA TODAY Sports for potential injury updates on the 49ers' two offensive stars.

49ers hold six-point lead after three quarters

Seattle is primed to get the ball back to start the fourth quarter after forcing a three-and-out from the 49ers following the Kenneth Walker touchdown. The Seahawks are one touchdown and 15 minutes away from extending their lead atop the NFC West.

49ers 23, Seahawks 17: Kenneth Walker powers into the end zone

The Seahawks strung together a 13-play, 94-yard drive to score their first offensive touchdown of the game. Kenneth Walker capped it all off with a couple of rushes up the middle inside the 49ers' 15-yard line before finally hammering the ball home on a 1-yard touchdown run. The 49ers' lead is down to 23-17 after Jason Myers' PAT attempt was good.

Geno Smith connects with Tyler Lockett on deep ball

Smith had been struggling on pass attempts for much of the evening before his fortune started to shift. He found Lockett on a 37-yard deep pass with just over five minutes left in the third quarter and brought the Seahawks from their own 21-yard line into 49ers territory.

Jordan Mason back in the medical tent

Jordan Mason's return to the game after his initial shoulder injury was short-lived. ESPN's Adam Schefter reported that the running back went to the medical tent after just one carry in the second half.

49ers 23, Seahawks 10: Laviska Shenault returns the kickoff for a touchdown

Laviska Shenault, the Seattle kick returner who fumbled a kickoff return in the second quarter, redeemed himself early in the third quarter. He broke through the 49ers' kickoff coverage team for a 97-yard kickoff return touchdown, and cut Seattle's deficit back down to 13 points. It's 23-10 49ers with 10 minutes remaining in the third quarter.

Shenault's kickoff return touchdown is the second in the NFL this season after the league changed its kickoff rules in the offseason. DeeJay Dallas of the Arizona Cardinals had the first one in Week 1 against the Buffalo Bills.

49ers 23, Seahawks 3: Brock Purdy hits George Kittle for a touchdown

Brock Purdy placed a perfect pass to his tight end to cap the 49ers' 70-yard drive with a touchdown. The 10-yard pass to George Kittle was Purdy's second touchdown throw of the game, and it extended the San Francisco lead to 23-3.

The third-year quarterback is 11-of-17 on pass attempts for 178 yards and two touchdown passes. He holds a 138.8 passer rating five minutes into the second half. Kittle is leading 49ers pass-catchers with his four catches and is second on the team with 49 receiving yards on the night.

Jordan Mason back from locker room

Jordan Mason, who missed the final minutes of the second quarter dealing with a shoulder injury, returned to the field to start the second half. He ran for nine yards on the 49ers' first play of the third quarter but went back to the sideline after the run.

The Amazon Prime Video broadcast showed the running back working his sore shoulder as he watched the action on the field.

49ers 16, Seahawks 3: Seattle finally gets on the board before halftime

DK Metcalf was unable to get both feet inbounds on a potential touchdown catch in the penultimate play of the first half. As a result, the Seahawks were forced to settle for a 20-yard field goal to end the first 30 minutes of play. Kicker Jason Myers knocked it through to cut Seattle's deficit to 13 points.

San Francisco is set to receive the second-half kickoff.

49ers 16, Seahawks 0: Matthew Wright remains perfect on field goal attempts

Matthew Wright, the last-minute 49ers signee, is the team's leading scorer with two and a half minutes left in the first half. Wright's third field goal of the game gets him up to 10 points on the night (including his converted PAT). The latest kick further extended the San Francisco lead to 16-0.

Jordan Mason slow to get up, heads to locker room after run

49ers running back Jordan Mason took a run up the middle for 14 yards on the second play of the 49ers' third drive in the second quarter. After the play, Mason remained down on the field for a few extra moments, grabbing at his shoulder. Mason was able to get up and walk off the field on his own power, but he went to the locker room with medical personnel.

Amazon Prime Video sideline reporter Kaylee Hartung confirmed that the issue was with Mason's shoulder and that he is questionable to return to the game.

Rookie Isaac Guerendo takes over in the backfield.

49ers 13, Seahawks 0: Matthew Wright knocks through another field goal

San Francisco couldn't take full advantage of their good field position following the fumble on the kickoff. The Seahawks' defense held the 49ers to just six yards, and the offense had to settle for a 41-yard field goal attempt.

Matthew Wright split the uprights for his second field goal of the game, and San Francisco extended their lead to 13-0. Seattle's offense will take the field with just under 12 minutes left in the half.

Laviska Shenault fumbles the ensuing kickoff

The 49ers have the ball at the Seahawks' 30-yard line one play later after kick returner Laviska Shenault lost the football. Wright's kick went into the end zone, but Shenault tried to get some extra yardage on a return rather than taking the touchback to the 30-yard line.

Second-year cornerback Darrell Luter Jr. was the player who forced the fumble, and defensive lineman Robert Beal recovered it.

49ers 10, Seahawks 0: Deebo Samuel extends the 49ers' lead

Samuel took full advantage of blown coverage on a delayed fade route outside the numbers near the left sideline. A Seahawks defender dove past the wide-open receiver as he made the catch, and the speedy Samuel took care of the rest. He won his footrace to the end zone for a 76-yard catch-and-run.

Wright's PAT was good, and San Francisco now leads 10-0 one and a half minutes into the second quarter.

49ers lead after first quarter

Wright's short field goal is the difference in this game through one quarter of play. Outside of the 49ers' 90-yard field goal drive, the two teams have combined for two punts and an interception to kill their other three drives.

The Seahawks have the ball and will continue their drive to begin the second quarter.

49ers 3, Seahawks 0: Newcomer Matthew Wright scores his first points as a 49er

The 49ers signed journeyman kicker Matthew Wright on Tuesday after kicker Jake Moody suffered a high ankle sprain against the Cardinals last week. When San Francisco's drive stalled inside the Seahawks' 10-yard line with a couple of incomplete passes, the 28-year-old Wright got his newest team on the board with a 25-yard field goal.

Wright was briefly a member of the 49ers' practice squad in September 2023, but he didn't enter a game for the team until Thursday night. His last appearance in a regular-season game was for the Carolina Panthers during their Week 18 game against the Tampa Bay Buccaneers last year. He missed his sole kick, a 52-yard field goal attempt, in the game.

Jordan Mason breaks off a big run

Mason, who has taken over the primary back duties in San Francisco with Christian McCaffrey on injured reserve, has continued his strong third season as a pro. Mason took an inside handoff and broke a few tackles with his run up the middle. Seattle safety Julian Love eventually tracked him down, but not before the running back picked up 38 yards to get the 49ers to the Seahawks' 28-yard line and knocking on the door of the red zone.

Malik Mustapha picks off Geno Smith to end game's opening drive

On the sixth play of the Seahawks' opening drive, Geno Smith tried to get a pass to Tyler Lockett deep downfield on third down. The pass was overthrown, and 49ers rookie safety Malik Mustapha was the benefactor in his second career start. He picked off Smith's pass at his own 2-yard line before his momentum took him out of bounds. It was the first interception of his NFL career.

The 49ers take over from their own 3-yard line for their first offensive drive of the evening.

Seahawks vs. 49ers start time 

• Date: Thursday, Oct. 10, 2024 
• Time: 8:15 p.m. ET 

The Seahawks and 49ers game will kick off Week 6 of the 2024 NFL season with "Thursday Night Football" at 8:15 p.m. ET. 

RANKING NFL'S STADIUMS: Why Seattle's Lumen Field is the league's top venue

Seahawks vs. 49ers TV channel 

• Live stream: Amazon Prime Video 

"Thursday Night Football" will exclusively stream on Amazon Prime Video. 

Al Michaels (play-by-play) and Kirk Herbstreit (analyst) will be in the broadcast booth for Prime Video, with Kaylee Hartung (sideline) and Terry McAulay (rules analyst) providing additional coverage.

The Prime Video pregame, halftime and postgame shows feature Charissa Thompson as host, as well as former NFL players Ryan Fitzpatrick, Tony Gonzalez, Richard Sherman and Andrew Whitworth as analysts. Taylor Rooks is the feature reporter for Prime Video's "Thursday Night Football" coverage.

Seahawks vs. 49ers predictions, picks 

Here are the USA TODAY Sports staff’s predictions for the "Thursday Night Football" Week 6 matchup: 

• Lorenzo Reyes: 49ers 25, Seahawks 17 
• Tyler Dragon: 49ers 25, Seahawks 20 
• Jordan Mendoza: 49ers 26, Seahawks 20 

49ers vs. Seahawks inactive players: Charvarius Ward out

49ers' inactive players:

• QB Joshua Dobbs
• TE Brayden Willis
• CB Charvarius Ward
• LB Demetrius Flannigan-Fowles
• OL Ben Bartch
• K Jake Moody
• DT Jordan Elliott

Seahawks' inactive players:

• CB Riq Woolen
• LB Trevis Gipson
• C Olu Oluwatimi
• OG Sataoa Laumea
• WR Dareke Young
• DT Byron Murphy II
• DE Myles Adams

Seahawks vs. 49ers odds, moneyline, over/under 

The 49ers are favorites to defeat the Seahawks in Week 6, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024, including the ESPN BET app and Fanatics Sportsbook promo code. 

• Spread: 49ers (-3.5) 
• Moneyline: 49ers (-190); Seahawks (+155) 
• Over/under: 49

Not interested in this game? Our guide to NFL betting odds, picks, and spreads has you covered with "Sunday Night Football" odds and "Monday Night Football" odds. 

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Seahawks vs. 49ers weather update 

It's going to be a slightly chilly but clear night in Seattle with a high of 58 degrees at kickoff and a low of 51 at midnight. According to the Weather Channel, winds will max out at eight mph while chances of precipitation are at less than 10% for the game. 

NFC West standings 

The Seahawks enter the Week 6 “TNF” showdown in sole possession of first place in the NFC West. However, with a win tonight, San Francisco can move into a tie. 

• Seattle Seahawks: 3-2 
• Arizona Cardinals: 2-3 
• San Francisco 49ers: 2-3 
• Los Angeles Rams: 1-4 

➤ Complete NFL standings

NFL Week 6 picks, predictions and odds

• Chicago Bears vs. Jacksonville Jaguars
• Baltimore Ravens vs. Washington Commanders
• Green Bay Packers vs. Arizona Cardinals
• New England Patriots vs. Houston Texans
• New Orleans Saints vs. Tampa Bay Buccaneers
• Philadelphia Eagles vs. Cleveland Browns
• Tennessee Titans vs. Indianapolis Colts
• Denver Broncos vs. Los Angeles Chargers
• Las Vegas Raiders vs. Pittsburgh Steelers
• Carolina Panthers vs. Atlanta Falcons
• Dallas Cowboys vs. Detroit Lions
• New York Giants vs. Cincinnati Bengals 
• New York Jets vs. Buffalo Bills

Who is the highest-paid NFL player? 

The NFL's top 18 players in average annual salary are all quarterbacks, according to OverTheCap.com. Dallas Cowboys quarterback Dak Prescott became the league's highest-paid player on the season's opening Sunday, agreeing to a four-year, $240 million deal. Minnesota Vikings wide receiver Justin Jefferson is the first non-quarterback on the highest-paid list after striking a four-year, $140 million contract extension this offseason. 

• Complete list of the league’s highest-paid players

Who are the highest paid NFL players at each position?

We have a complete list at every position: 

• Quarterbacks
• Running backs
• Wide receivers
• Tight ends
• Offensive tackles
• Offensive guards
• Centers
• Edge rushers
• Interior defensive linemen
• Linebackers
• Cornerbacks
• Safeties
• Kickers
• Punters

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